Spanning more than 50 years, Friedrich Muller began his career in an unpromising apprenticeship as a Sanskrit scholar and culminated in virtually every honor that European governments and learned societies could bestow.
(A) Muller began his career in an unpromising apprenticeship as
(B) Muller's career began in an unpromising apprenticeship as
(C) Muller's career began with the unpromising apprenticeship of being
(D) Muller had begun his career with the unpromising apprenticeship of being
(E) the career of Muller has begun with an unpromising apprenticeship of
题目分析：前面的begin应该和后面的culminated保持一致。应该用began，用in表示的意思显然比用with号更何况C还加了一个诡异的with，A和B进行比较，发现主语不一样，但是人做不出来culminated这个动作，只有career可以做出来，选B
